|
Symbol Name ID |
Gnao1
guanine nucleotide binding protein, alpha O MGI:95775 |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Microcephaly |
Dysphagia |
Spasticity |
Delayed CNS myelination |
Atrophy/Degeneration affecting the brainstem |
Ventriculomegaly |
Hypoplasia of the corpus callosum |
Cerebral atrophy |
Cerebellar atrophy |
Athetosis |
Chorea |
Involuntary movements |
Multifocal epileptiform discharges |
EEG with burst suppression |
Hypsarrhythmia |
Absent speech |
Self-injurious behavior |
Intellectual disability, severe |
Dyskinesia |
Orofacial dyskinesia |
Dystonia |
Inability to walk |
Hyperkinetic movements |
Epileptic encephalopathy |
Global developmental delay |
Bilateral tonic-clonic seizure |
Focal impaired awareness seizure |
Focal tonic seizure |
Generalized tonic seizure |
Infantile spasms |
| Disease(s) Associated with GNAO1 | ||||||||||||||||||||||||||||||
| developmental and epileptic encephalopathy 17 | ||||||||||||||||||||||||||||||
| neurodevelopmental disorder with involuntary movements |
| Mouse Phenotypes | abnormal kindling response |
increased kindling response |
abnormal spike wave discharge |
sporadic seizures |
abnormal nervous system physiology |
abnormal vomeronasal sensory neuron physiology |
abnormal channel response |
|
| Availability | Mouse Genotype | |||||||
| Gnao1tm1Ejne/Gnao1tm1Ejne | ||||||||
| Gnao1tm1Lbi/Gnao1tm1Lbi | ||||||||
| Gnao1em1Rneu/Gnao1+ | ||||||||
| Gnao1tm2.1Rneu/Gnao1+ | ! | |||||||
| Gnao1tm2Rneu/Gnao1+ | ||||||||
| Gnao1tm4Lbi/Gnao1tm4Lbi Omptm4(cre)Mom/? (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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